Nur77 protects the bladder urothelium from intracellular bacterial

nuri77Overview of the antiinflammatory snaling pathway of the orphan nuclear receptor Nur77 in EC. LPS induces an increase of Nur77 expression that negatively regulates endothelialNur77 (also known as TR3 and NGFI-B) is nuclear receptor subfamily 4 group A member 1 (NR4A1) 1, 2, 3, 4.In general, it acts as a transcription factor localized in the nucleus